Feasibility Simulation of 3D Benchtop Multi-Pinhole X-ray Fluorescence Computed Tomography with Two Novel Geometries

In this work, we developed and validated two novel imaging geometries of benchtop multi-pinhole X-ray fluorescence computed tomography (XFCT) systems with Geant4 Toolkit. One the Monte Carlo (MC) models utilized a fan beam source to illuminate single slice object, detector collimator image each slice’s (XRF). The other model consisted cone-beam (designed as 5 mm wide reduce simulation time) scan whole detectors collimators emissions. phantom used in simulations included four sections, three cone-shaped gold nanoparticle (GNP) inserts (5 height, 3 diameter across top) center-to-center distances 4 mm, 4.5 4.86 mm. GNPs concentration was 0.1 wt. %, 0.3 0.5 % 0.7 respectively. 1 Performance evaluated for pinhole-detector-distance (PDD) cm, 3.5 cm 2.5 results different object layers pinhole (9 pinholes) were compared. data showed that worsened decreasing insert diameters PDD (object-pinhole-distance fixed). configurations performed better than pinhole. detection limit first operation 0.21 %; second 0.24 %. Detection limits 0.32 0.35 MC could acquire 2D images without rotation 3D efficiently. These potentially provide bioimaging modality nanomedical applications.